| PUBLICATIONS
 2012
Fujimoto M, Hayashi H , Takagi Y , Hayase M , Marumo T , Gomi M , Nishimura M , Kataoka H , Takahashi J ,Hashimoto N , Nozaki K , Miyamoto S. Transplantation of telencephalic neural progenitors induced from embryonic stem cells into subacute phase of focal cerebral ischemia. Lab Invest. 92: 522-531 (2012)
Doi D, Morizane A, Kikuchi T, Onoe H, Hayashi T, Kawasaki T, Motono M, Sasai Y, Saiki H, Gomi M, Yoshikawa T, Hayashi H, Shinoyama M, Mohamed R, Suemori H, Miyamoto S, Takahashi J. Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson’s disease. Stem Cells 30(5): 935-945 (2012)
Shinoyama M, Ideguchi M, Hayashi H, Doi D, Hashimoto N, Suzuki M, Takahashi J. CTLA4-Ig promotes neuronal differentiation in the grafts of embryonic stem cell-derived neural precursor cells. Neuroscience 202: 484-491 (2012)
Kitamura A, Fujita Y, Oishi N, Kalaria RN, Washida K, Maki T, Okamoto Y, Hase Y, Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M. Selective white matter abnormalities in a novel rat model of vascular dementia. Neurobiol Aging. 33(5):1012.e25-35 (2012)
2011
Kikuchi T, Morizane A, Doi D, Onoe H, Hayashi T, Kawasaki T, Saiki H, Miyamoto S, Takahashi J. Survival of human induced pluripotent stem cell–derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson's disease. J Parkinson’s Disease 1(4): 395-412 (2011)
Gomi M, Aoki T, Takagi Y, Nishimura M, Ohsugi Y, Mihara M, Nozaki K, Hashimoto N, Miyamoto S, Takahashi J. Single and local blockade of IL-6 signaling promotes neuronal differentiation of transplanted ES cell-derived neural precursor cells. J Neurosci Res 89(9): 1388-1399 (2011)
Okita K, Matsumura Y , Sato Y, Okada A, Morizane A, Okamoto S, Hong Hyenjong, Nakagawa M, Tanabe K, Tezuka K, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S. A more efficient method to generate integration-free human iPS cells. Nature Methods, 8(5): 409-412 (2011)
Morizane A, Doi D, Kikuchi T, Nishimura K, Takahashi J. Small Molecule Inhibitors of BMP and Activin/Nodal Signals Promote Highly Efficient Neural Induction from Human Pluripotent Stem Cells. J Neurosci Res, 89(2): 117-126 (2011)
2010
Morizane A, Darsalia V, Guloglu MO, Hjalt T, Carta M, Li JY, Brundin P, A simple method for large-scale generation of dopamine neurons from human embryonic stem cells, J Neurosci Res 88(16): 3467-78 (2010)
Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R. Nonhypotensive dose of Telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-g activation in mice with chronic cerebral hypoperfusion. Stroke 41(8): 1798-1806 (2010)
Saiki H, Hayashi T, Takahashi R, Takahashi J. Objective and quantitative evaluation of motor function in a monkey model of Parkinson’s disease. J Neurosci Methods 190(2): 198-204 (2010)
Morizane A and Takahashi J. Embryonic stem cell transplantation for the treatment of Parkinson’s disease. in Perspectives of Stem Cells. H. Ulrich (Ed.) Springer, pp245-254 (2010)
Anisimov SV, Morizane A, Correia AS. Risks and mechanisms of oncological disease following stem cell transplantation. Stem Cell Rev and Rep 6(3): 411-424 (2010)
Uemura M, Refaat M. M, Shinoyama M, Hayashi H, Hashimoto N, Takahashi J. Matrigel supports survival and neuronal differentiation of grafted embryonic stem cell-derived neural precursor cells. J Neurosci Res 88(3): 542-551 (2010)
2009
Takahashi J, Takagi Y, Saiki H. Transplantation of Embryonic Stem Cell-Derived Dopaminergic Neurons in MPTP-Treated Monkeys. Methods Mol Biol 482: 199-212 (2009)
2008
Wataya T, Ando S, Muguruma K, Ikeda H, Watanabe K, Eiraku M, Kawada M, Takahashi J, Hashimoto N, Sasai Y. Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation. Proc Natl Acad Sci USA 105(33): 11796-11801 (2008)
Ideguchi M, Shinoyama M, Gomi M, Hayashi H, Hashimoto N, Takahashi J. Immune or inflammatory response by the host brain suppresses neuronal differentiation of transplanted ES cell-derived neural precursor cells. J Neurosci Res 86(9): 1936-1943 (2008)
Hayashi H, Morizane A, Koyanagi M, Ono Y, Sasai Y, Hashimoto N, Takahashi J. Meningeal cells induce dopaminergic neurons from embryonic stem cells. Eur J Neurosci 27: 261-268 (2008)
Koyanagi M, Takahashi J, Arakawa Y, Doi D, Fukuda H, Hayashi H, Narumiya S, Hashimoto N. Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. J Neurosci Res 86(2): 270-280 (2008)
2007
Takahashi J. Stem cell therapy for Parkinson’s disease. Expert Rev Neurother 7: 667-675 (2007)
Ono Y, Nakatani T, Sakamoto Y, Mizuhara E, Minaki Y, Kumai M, Hamaguchi A, Nishimura M, Inoue Y, Hayashi H, Takahashi J, Imai T. Differences in neurogenic potential in floor plate cells along an antero-posterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells. Development 134(17): 3213-3225 (2007)
Watanabe K, Ueno M, Kamiya D, Nishiyama A, Matsumura M, Wataya T, Takahashi J, Nishikawa S, Nishikawa S-I, Muguruma K, Sasai Y. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotech 25: 681-686 (2007)
Takahashi J, Morizane A. Embryonic stem cell-derived neurons and astrocytes. in Neuroscapes: Book in honour of Santiago Ramón y Cajal. DeFelipe, J., Markram, H., Wagensberg, J. (Eds.) Spanish National Research Council, Madrid, Spain, 226-227&309 (2007)
2006
Takahashi J. Stem cell therapy for Parkinson’s disease. in Stem Cells in Reproduction and in the Brain. J. Morser, S-I. Nishikawa, HR. Scholer (Eds.) Springer pp229-244 (2006)
Brederlau A, Correia AS, Anisimov SV, Elmi M, Roybon L, Paul G, Morizane A, Bergquist F, Riebe I, Nannmark U, Carta M, Hanse E, Takahashi J, Sasai Y, Funa K, Brundin P, Eriksson PS, Li JY. Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson’s disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells 24: 1433-1440 (2006)
Hayashi J, Takagi Y, Fukuda H, Imazato T, Nishimura M, Fujimoto M, Takahashi J, Hashimoto N, Nozaki K. Primate embryonic stem cell-derived neural progenitors transplanted into ischemic brain. J Cereb Blood Flow Metab. 26: 906-914 (2006)
Morizane A, Takahashi J, Shinoyama M, Ideguchi M, Takagi Y, Fukuda H, Koyanagi M, Sasai Y, Hashimoto N. Generation of graftable progenitors of dopaminergic neurons from mouse ES cells by a combination of co-culture and neurosphere methods. J Neurosci Res. 83: 1015-1027 (2006)
Fukuda H, Takahashi J, Watanabe K, Hayashi H, Morizane A, Koyanagi M, Sasai Y, Hashimoto N. FACS-based purification of ES cell-derived neural precursors averts tumor formation after transplantation. Stem Cells 24: 763-771 (2006)
2005
Takagi Y, Nishimura M, Morizane A, Takahashi J, Nozaki K, Hayashi J, Hashimoto N. Survival and differentiation of neural progenitor cells derived from embryonic stem cells and transplanted into ischemic brain. J Neurosurg. 103: 304-310 (2005)
Takagi Y and Takahashi J. Primate embryonic stem cells as a source of dopaminergic neurons: a novel transplantation for Parkinson’s disease. Disc Med. 5:219-223 (2005)
Fukuda H and Takahashi J. Embryonic stem cells as a cell source for treating Parkinson’s disease. Expert Opin Biol Ther. 5: 1273-1280 (2005)
Kishi Y, Takahashi J, Koyanagi M, Morizane A, Okamoto Y, Horiguchi S, Tashiro K, Honjo T, Fujii S, Hashimoto N. Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells. J Neurosci Res. 79(3): 279-286 (2005)
Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, Fukuda H, Okamoto Y, Koyanagi M, Ideguchi M, Hayashi H, Imazato T, Kawasaki H, Suemori H, Omachi S, Iida H, Itoh N, Nakatsuji N, Sasai Y, Hashimoto N. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest. 115(1): 102-109 (2005)
2004
Horiguchi S, Takahashi J, Kishi Y, Morizane A, Okamoto Y, Koyanagi M, Tsuji M, Tashiro K, Honjo T, Fujii S, Hashimoto N. Neural precursor cells derived from human embryonic brain retain regional specificity. J Neurosci Res. 75(6):817-824 (2004)
2003
Toda H, Tsuji M, Nakano I, Kobuke K, Hayashi T, Kasahara H, Takahashi J, Mizoguchi A, Houtani T, Sugimoto T, Hashimoto N, Palmer TD, Honjo T, Tashiro K. Stem cell-derived neural stem/progenitor cell supporting factor (SDNSF) is an autocrine/paracrine survival factor for neural stem/progenitor cells. J Biol Chem. 278(32): 35491-35500 (2003)
2002
Morizane A, Takahashi J, Takagi Y, Sasai Y, Hashimoto N. Optimal conditions for in vivo induction of dopaminergic neurons from ES cells through stromal cell-derived inducing activity. J Neurosci Res 69(6):934-939 (2002)
Takahashi J, Toda H, Hashimoto N. Neural stem cells as a tool for cell transplantation. in Strategic Medical Science Against Brain Attack.H.Kikuchi(Ed.) Springer-Verlag Tokyo pp3-20 (2002)
2001
Toda H, Takahashi J, Iwakami N, Kimura T, Hoki S, Mozumi-Kitamura K, Ono S, Hashimoto N. Grafting neural stem cells improved the impaired spatial recognition in ischemic rats. Neurosci Lett 316:9-12 (2001)
Wu S, Suzuki Y, Kitada M, Kitaura M, Kataoka K, Takahashi J, Ide C, Nishimira Y. Migration, integration, and differentiation of hippocampus-derived neurosphere cells after transplantation into injured rat spinal cord. Neurosci Lett 312:173-176 (2001)
Tanigaki K, Nozaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T. Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate. Neuron 29:45-55 (2001)
2000
Nishida A, Takahashi M, Tanihara H, Nakano I, Takahashi J, Mizoguchi A, Ide C, Honda Y. Incorporation and differentiation of hippocampus-derived neural stem cells transplanted in injured adult rat retina. Invest Ophthalmol Vis Sci. 41:4268-4274 (2000)
Toda H, Takahashi J, Mizoguchi A, Koyano K, Hashimoto N. Neurons generated from adult rat hippocampal stem cells form functional glutamatergic and GABAergic synapses in vitro. Exp Neurol. 165:66-76 (2000)
- 1999
Takagi Y, Nozaki K, Takahashi J, Yodoi J, Ishikawa M, Hashimoto N. Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice. Brain Res. 831:283-287 (1999)
Takahashi J, Palmer TD, Gage FH. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J. Neurobiol. 38:65-81 (1999)
Takahashi M, Takahashi J, Palmer TD, Gage FH. Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol. Cell. Neurosci. 12(6):340-348 (1998)
Palmer TD, Takahashi J, Gage FH. The adult rat hippocampus contains primordial neural stem cells. Mol. Cell. Neurosci. 8:389-404 (1997)
Nakajima T, Fukamizu A, Takahashi J, Gage FH, Fisher T, Blenis J, Montminy MR. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell 86:465-474 (1996)
Ray J, Palmer TD, Suhonen J, Takahashi J, Gage FH.Neurogenesis in the Adult Brain: Lessons Learned from the Studies of Progenitor Cells from the Embryonic and Adult Central Nervous System.in Isolation, Characterization and Utilization of CNS Stem Cells. Gage FH and Christen Y, Eds.,Foundation IPSEN, Paris, France.pp 129-149 (1996)
Kojima M, Hoshimaru M, Aoki T, Takahashi J, Otsuka T, Asahi M, Matsuura N, Kikuchi H. Expression of heat shock proteins in the developing rat retina. Neurosci. Lett. 205:215-7 (1996)
Koide T, Takahashi J, Hoshimaru M, Kojima M, Otsuka T, Asahi M, Kikuchi H. Localization of trkB and low-affinity nerve growth factor receptor mRNA in the developing rat retina. Neurosci. Lett. 185:183-6 (1995)
Takahashi J, Hoshimaru M, Kikuchi H, Hatanaka M. Developmental expression of trkB and low-affinity NGF receptor in the rat retina. Neurosci. Lett. 151:174-177 (1993)
Takahashi J, Hoshimaru M, Kikuchi H, Hatanaka M. Extension of optic nerve fibers on genetically modified cells producing brain-derived neurotrophic factor. Neurosci. Lett. 149:83-86 (1993)
Takahashi J, Hoshimaru M, Kikuchi H, Hatanaka M. Possible activity of acidic fibroblast growth factor as a progression factor rather than a transforming factor. Biochem. Biophys. Res. Commun. 189:398-405 (1992)
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