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53 Kawahara-cho, Shogoin,
Sakyo-ku,Kyoto 606-8507,
JAPAN
Department of Biological Repair,
Field of Clinical Application,
Institute for Frontier Medical Sciences,
Kyoto University
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We are developing a cell replacement therapy for the neurological disorders by using stem cells, especially embryonic stem cells (ES cells). The main target is Parkinson's disease, and our research focuses on induction of dopaminergic neurons from ES cells and transplantation of the cells into the brain to improve neurological symptoms.
We have revealed the optimal differentiational stage for an efficient survival of the grafted dopaminergic neurons, and also a method to prevent tumor formation. In addition, we have demonstrated that transplantation of monkey ES cell-derived neurons improved the Parkinsonian symptoms of the monkey models. As a next step, we hope to examine the long-term efficacy and safety of human ES cell transplantation in primate models. |
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| Associate Professor
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Jun Takahashi
MD, PhD
Neurosurgeon
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| Researcher |
Asuka Morizane
MD, PhD
Neurosurgeon
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Daisuke Doi
MD
Neurosurgeon |
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Kaneyasu Nishimura
PhD
CV (PDF) |
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Makoto Motono
PhD |
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Tetsuhiro Kikuchi
MD
Neurosurgeon
CV (PDF) |
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| Project Manager |
Ryuta Asada |
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| Technical staff |
Kei Kubota |
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Emi Yamasaki |
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Ariko Fuke |
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| Administrative staff |
Toshiko Gomibuchi |
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Graduate students
(A Ph.D. program) |
Tatsuya Yoshikawa
MD
Neurosurgeon |
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Aya Ogura |
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Yoshihiko Ioroi
MD
Neurosurgeon |
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Yasushi Koshiba
MD
Neurologist |
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Bunpei Samata |
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Graduate students
(A master's course) |
Mitsuko Katsukawa |
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| Medical students |
Yusuke Nakajima |
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 Institute for Frontier Medical Sciences, KyotoUniversity
Department of Neurosurgery, Graduate School of Medicine, KyotoUniversity
Kyoto University
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